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. 1970 Aug;66(4):1089-95.
doi: 10.1073/pnas.66.4.1089.

Immunological alteration of leukemic cells in vivo after treatment with an antitumor drug

E Bonmassar, A Bonmassar, S Vadlamudi, A Goldin

Immunological alteration of leukemic cells in vivo after treatment with an antitumor drug

E Bonmassar et al. Proc Natl Acad Sci U S A. 1970 Aug.

Abstract

L1210 leukemia was transplanted serially in CDF(1) mice treated with 5-(3,3-dimethyl-1-triazeno)imidazole-4-carboxamide (DIC, NSC 45388). After four different lines (C lines) had been treated for several generations, a marked increase in survival time of untreated mice was observed. In contrast, mice treated with DIC or immunosuppressed with cyclophosphamide succumbed earlier with generalized leukemia. Furthermore, a C line showed unusually high sensitivity to chemotherapeutic treatment with 1,3 bis(2-chloroethyl)-1-nitrosourea. The data suggest that C lines acquired strong antigenicity for CDF(1) and DBA/2 hosts. DIC treatment may have selected highly antigenic variants or induced somatic mutations resulting in the appearance of strong new transplantation antigen(s).

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