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. 1970 Aug;66(4):1183-9.
doi: 10.1073/pnas.66.4.1183.

Immunoglobulin synthesis and secretion. V. Incorporation of leucine and glucosamine into immunoglobulin on free and bound polyribosomes

C J Sherr, J W Uhr

Immunoglobulin synthesis and secretion. V. Incorporation of leucine and glucosamine into immunoglobulin on free and bound polyribosomes

C J Sherr et al. Proc Natl Acad Sci U S A. 1970 Aug.

Abstract

Mouse myeloma cells pulse-labeled in vitro with (3)H-leucine or (3)H-glucosamine were fractionated on sucrose gradients, and membrane-bound and free polyribosomes were separated. Nascent polypeptides released from polyribosomes were precipitated with antiserum specific for mouse immunoglobulin. The results indicate that immunoglobulin is synthesized preferentially by bound polyribosomes.

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References

    1. Biochem J. 1965 Nov;97(2):422-31 - PubMed
    1. J Biol Chem. 1966 Mar 10;241(5):1150-8 - PubMed
    1. J Biol Chem. 1966 Nov 25;241(22):5408-18 - PubMed
    1. J Theor Biol. 1966 Jan;10(1):89-113 - PubMed
    1. Proc Natl Acad Sci U S A. 1966 Jul;56(1):216-21 - PubMed

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