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. 1970 Aug;66(4):1206-12.
doi: 10.1073/pnas.66.4.1206.

Axon growth: roles of microfilaments and microtubules

K M Yamada, B S Spooner, N K Wessells

Axon growth: roles of microfilaments and microtubules

K M Yamada et al. Proc Natl Acad Sci U S A. 1970 Aug.

Abstract

The motile tips of elongating axons consist of growth cones from which microspikes protrude. Cytochalasin B causes retraction of microspikes, rounding-up of growth cones, and cessation of axon elongation. Drug withdrawal is followed by resumption of growth cone and microspike activity and of axon elongation. In contrast, colchicine causes shortening and retraction of axons, but it does not initially affect the tips. Growth cones and microspikes of elongating axons contain a network of 50 A microfilaments, the pattern of which is altered by cytochalasin treatment. These experiments indicate that both structural integrity of the axon and continuing function of its motile tip are essential elements in axonal elongation.

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References

    1. J Exp Zool. 1969 Jul;171(3):359-67 - PubMed
    1. Proc Natl Acad Sci U S A. 1956 Sep;42(9):695-9 - PubMed
    1. Exp Neurol. 1969 Feb;23(2):230-48 - PubMed
    1. J Cell Biol. 1967 Jan;32(1):113-9 - PubMed
    1. Nature. 1967 Jan 21;213(5073):261-4 - PubMed

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