doi: 10.1073/pnas.66.1.111.
Secondary structure of the cyclic moiety of the peptide hormone oxytocin and its deamino analog
- PMID: 5273889
- PMCID: PMC286095
- DOI: 10.1073/pnas.66.1.111
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Secondary structure of the cyclic moiety of the peptide hormone oxytocin and its deamino analog
Proc Natl Acad Sci U S A.
1970 May.
Abstract
The secondary structure of the cyclic moiety of oxytocin and deamino-oxytocin has been determined by nuclear magnetic resonance spectroscopy (220 MHz). Oxytocin, in a dimethylsulfoxide-methanol mixture, contains a beta-turn involving the sequence -L-tyrosyl-L-isoleucyl-L-glutaminyl-L-asparaginyl-. Deamino-oxytocin, in addition to the beta-turn, contains a hydrogen bond involving the amide hydrogen of the tyrosine residue and the peptide carbonyl group of the asparagine residue, resulting in an antiparallel beta-type conformation for the ring component. An initial attempt has been made to relate conformational features of the hormonal peptides to their biological activity.
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