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. 1970 Nov;67(3):1192-9.
doi: 10.1073/pnas.67.3.1192.

A genetic marker in the variable region of light chains of mouse immunoglobulins

G M Edelman, P D Gottlieb

A genetic marker in the variable region of light chains of mouse immunoglobulins

G M Edelman et al. Proc Natl Acad Sci U S A. 1970 Nov.

Abstract

A genetic variation was observed upon autoradiographic comparison of tryptic peptide maps of (14)C-labeled normal light chains from 17 different inbred strains of mice. The difference was found in strains AKR/J, C58/J, and RF/J. Chemical analyses showed that the differences were in a region of the amino acid sequence in the neighborhood of half-cystine I of the variable region of the light chain. Breeding experiments showed that the difference segregated in a classical Mendelian fashion.

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