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. 1970 Nov;67(3):1493-500.
doi: 10.1073/pnas.67.3.1493.

Development of insulin-sensitivity by mouse mammary gland in vitro

S H Friedberg, T Oka, Y J Topper

Development of insulin-sensitivity by mouse mammary gland in vitro

S H Friedberg et al. Proc Natl Acad Sci U S A. 1970 Nov.

Abstract

Explants from mammary gland of pregnant mice are sensitive to insulin, but corresponding explants from mature, virgin mice are insensitive to insulin in certain respects. Isolated virgin tissue can acquire insulin-sensitivity independent of exogenous insulin. Some endocrinological and developmental implications are discussed.

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