Superposition of excitatory and inhibitory influences in the retina of Limulus: effect of delayed inhibition

Abstract

In an optic nerve fiber of the compound eye of the horseshoe crab, Limulus, the time course of a train of nerve impulses discharged in response to illumination reflects the interplay of excitatory and inhibitory influences. Responses to sinusoidally modulated excitation and inhibition, as a function of frequency, were measured separately and in combination. A simple linear superposition of the separate frequency responses properly accounts for the composite frequency response for both synchronous and asynchronous modulation of the excitatory and inhibitory influences. In general, the effect on the frequency response of increasing the delay of the inhibitory influence is progressively to shift the maximum amplitude to lower frequencies and gradually to produce pronounced maxima and minima in both the amplitude and phase.