doi: 10.1073/pnas.68.1.116.
Mitotic separation of two human X-linked genes in man--mouse somatic cell hybrids
- PMID: 5276281
- PMCID: PMC391174
- DOI: 10.1073/pnas.68.1.116
Item in Clipboard
Mitotic separation of two human X-linked genes in man--mouse somatic cell hybrids
Proc Natl Acad Sci U S A.
1971 Jan.
Abstract
SIX INTERSPECIFIC SOMATIC HYBRID CELL LINES WERE DERIVED FROM A MOUSE LINE DEFICIENT IN HYPOXANTHINE: guanine phosphoribosyltransferase (HGPRT) and human diploid cells with normal enzyme activity. Human HGPRT was present in all six hybrids and the clones derived from them. However, in two of the six, and in some clones from another two, human glucose-6-phosphate dehydrogenase (G6PD) was absent. Since the structural loci for both these enzymes are X-linked in man, these findings suggest that these two loci have separated quite frequently through chromosome breakage and that they must be rather far apart on the X chromosome.
Similar articles
-
Human-mouse somatic cell hybrids with single human chromosome (group E): link with thymidine kinase activity.Science. 1968 Nov 29;162(3857):1005-6. doi: 10.1126/science.162.3857.1005. Science. 1968. PMID: 5698836
-
Hybridization of human diploid strains carrying X-linked mutants and its potential in studies of somatic cell genetics.Wistar Inst Symp Monogr. 1969;9:117-36. Wistar Inst Symp Monogr. 1969. PMID: 5366450 No abstract available.
-
Linkage relationships of seventeen human gene loci as determined by man--mouse somatic cell hybrids.Nat New Biol. 1971 Jul 21;232(29):69-73. doi: 10.1038/newbio232069a0. Nat New Biol. 1971. PMID: 5285340 No abstract available.
-
Utilization of somatic cell hybrids for genetic studies in man.Humangenetik. 1973;19(1):1-40. doi: 10.1007/BF00295233. Humangenetik. 1973. PMID: 4353600 Review. No abstract available.
-
Electrophoretic variation in enzymes.Science. 1965 Aug 27;149(3687):936-43. doi: 10.1126/science.149.3687.936. Science. 1965. PMID: 5318249 Review. No abstract available.
Cited by
-
Restoration of hypoxanthine phosphoribosyl transferase activity in mouse 1R cells after fusion with chick-embryo fibroblasts.Proc Natl Acad Sci U S A. 1973 Jul;70(7):1998-2002. doi: 10.1073/pnas.70.7.1998. Proc Natl Acad Sci U S A. 1973. PMID: 4516198 Free PMC article.
-
Linkage relationships of X-linked enzymes glucose-6-phosphate dehydrogenase and hypoxanthine guanine phosphoribosyltransferase: recombination in female offspring of compound heterozygotes.Am J Hum Genet. 1974 Jul;26(4):512-22. Am J Hum Genet. 1974. PMID: 4842775 Free PMC article. No abstract available.
-
X-linkage of human phosphoglycerate kinase confirmed in man-mouse and man-Chinese hamster somatic cell hybrids.Am J Hum Genet. 1971 Nov;23(6):614-23. Am J Hum Genet. 1971. PMID: 5132070 Free PMC article. No abstract available.
-
Simplified methods for the measurement and electrophoretic demonstration of hypoxanthine-guanine phosphoribosyl transferase. Evidence for dimeric enzyme structure in various mammals.Humangenetik. 1972;17(1):69-74. doi: 10.1007/BF01789603. Humangenetik. 1972. PMID: 4119156 No abstract available.
-
Disparate enzyme activity in erythocytes and leukocytes. A variant of hypoxanthine phosphoribosyl-transferase deficiency with an unstable enzyme.J Clin Invest. 1973 Aug;52(8):2068-74. doi: 10.1172/JCI107391. J Clin Invest. 1973. PMID: 4352580 Free PMC article.
References
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Miscellaneous
