doi: 10.1073/pnas.68.1.234.
Genes for neuronal properties expressed in neuroblastoma x L cell hybrids
- PMID: 5276295
- PMCID: PMC391202
- DOI: 10.1073/pnas.68.1.234
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Genes for neuronal properties expressed in neuroblastoma x L cell hybrids
Proc Natl Acad Sci U S A.
1971 Jan.
Abstract
Neuroblastoma cells with electrically excitable membranes were fused with electrically passive L cells having a hitherto undescribed electrical marker. Hybrid cells, examined 10-40 generations after fusion, were found to be electrically excitable. The results show that at least a part of the genetic information for neuron differentiation can be functionally expressed in N x L hybrid cells. Evidence for the regulation of action potential components was also found.
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