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. 1971 Jan;68(1):240-3.
doi: 10.1073/pnas.68.1.240.

A thrombin-sensitive protein of human platelet membranes

N L Baenziger, G N Brodie, P W Majerus

A thrombin-sensitive protein of human platelet membranes

N L Baenziger et al. Proc Natl Acad Sci U S A. 1971 Jan.

Abstract

The action of thrombin on intact human platelets has been studied with the aid of polyacrylamide gel electrophoresis in sodium dodecylsulfate. A single major membrane protein band with a molecular weight of 190,000 disappears after thrombin treatment, while a new membrane protein with a molecular weight of 107,000 appears. This may represent hydrolysis of the thrombin-sensitive protein. When platelets are disrupted or when the thrombin-sensitive protein is solubilized from membranes prior to thrombin treatment, no hydrolysis occurs. The effect of thrombin on the platelet membrane protein is complete within 2 min which suggests that hydrolysis of this membrane protein may trigger the physiological effects of thrombin on platelets.

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