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. 1971 Mar;68(3):619-24.
doi: 10.1073/pnas.68.3.619.

Mammalian peptide chain termination. II. Codon specificity and GTPase activity of release factor

A L Beaudet, C T Caskey

Mammalian peptide chain termination. II. Codon specificity and GTPase activity of release factor

A L Beaudet et al. Proc Natl Acad Sci U S A. 1971 Mar.

Abstract

In vitro peptide chain termination with release factor preparations from rabbit reticulocytes, guinea pig liver, or Chinese hamster liver is directed with UAAA, UAGA, or UGAA, suggesting that UAA, UAG, and UGA are terminator condons for mammalian cells. Purified release factor from rabbit reticulocytes has ribosomaldependent GTPase activity, which is stimulated by UAAA. GTP hydrolysis appears requisite for in vitro peptide chain termination in mammals.

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