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. 1971 Feb;68(2):283-6.
doi: 10.1073/pnas.68.2.283.

Temperature-dependent surface changes in cells infected or transformed by a thermosensitive mutant of polyoma virus

W Eckhart, R Dulbecco, M M Burger

Temperature-dependent surface changes in cells infected or transformed by a thermosensitive mutant of polyoma virus

W Eckhart et al. Proc Natl Acad Sci U S A. 1971 Feb.

Abstract

Infection of BALB/3T3 cells by polyoma virus causes an alteration in the cell surface, characterized by enhanced agglutination of the cells by wheat germ agglutinin or concanavalin A. Infection by the thermosensitive mutant of polyoma, ts-3, causes the cell surface alteration at the permissive temperature, but not at the nonpermissive temperature. The cell surface alteration requires cellular DNA synthesis, but not viral DNA synthesis. BHK cells transformed by ts-3 show the surface alteration when grown at the permissive temperature, but not when grown at the nonpermissive temperature. It is concluded that the surface alteration in transformed cells is under the control of a viral gene.

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References

    1. Nature. 1968 Aug 3;219(5153):499-500 - PubMed
    1. Proc Natl Acad Sci U S A. 1970 Sep;67(1):394-9 - PubMed
    1. Proc Natl Acad Sci U S A. 1963 Oct;50:613-9 - PubMed
    1. Proc Natl Acad Sci U S A. 1967 Feb;57(2):359-66 - PubMed
    1. Virology. 1969 May;38(1):120-5 - PubMed

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