Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1971 Feb;68(2):378-82.
doi: 10.1073/pnas.68.2.378.

Hemoglobin synthesis in murine virus-induced leukemic cells in vitro: stimulation of erythroid differentiation by dimethyl sulfoxide

C Friend, W Scher, J G Holland, T Sato

Hemoglobin synthesis in murine virus-induced leukemic cells in vitro: stimulation of erythroid differentiation by dimethyl sulfoxide

C Friend et al. Proc Natl Acad Sci U S A. 1971 Feb.

Abstract

Cells of a cloned line of murine virus-induced erythroleukemia were stimulated to differentiate along the erythroid pathway by dimethyl sulfoxide at concentrations that did not inhibit growth. A rise in the number of benzidine-positive normoblasts was accompanied by increased synthesis of heme and hemoglobin and a decrease in the malignancy of the cells. This action of dimethyl sulfoxide, which was reversible, may represent the derepression of leukemic cells to permit their maturation.

PubMed Disclaimer

References

    1. Biochem Biophys Res Commun. 1966 May 25;23(4):557-60 - PubMed
    1. J Gen Virol. 1969 Apr;4(3):449-52 - PubMed
    1. Proc Soc Exp Biol Med. 1963 Apr;112:1058-62 - PubMed
    1. Ann N Y Acad Sci. 1967 Mar 15;141(1):532-50 - PubMed
    1. Science. 1962 Dec 28;138(3548):1399-403 - PubMed

Substances