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. 1971 Feb;68(2):505-8.
doi: 10.1073/pnas.68.2.505.

Asynchronous synthesis of the complementary strands of the reovirus genome

M Schonberg, S C Silverstein, D H Levin, G Acs

Asynchronous synthesis of the complementary strands of the reovirus genome

M Schonberg et al. Proc Natl Acad Sci U S A. 1971 Feb.

Abstract

The mechanism of replication of the double-stranded RNA genome of reovirus has been analyzed by tracing the fate of the parental double-stranded RNA genome and by determining whether the complementary strands, which comprise the progeny double-stranded RNA, are synthesized simultaneously or sequentially. The results indicate that the parental double-stranded RNA is conserved as the original duplex molecule within a subviral particle throughout the viral replicative cycle. The complementary strands, which form the progeny double-stranded RNA, are produced asynchronously. Minus strands are synthesized on preformed plus-strand templates, whereas plus strands appear to be synthesized on double-stranded RNA templates.

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