Bile acid clearance in liver disease

Abstract

The disappearance of intravenously administered cholylglycine-14C was studied in the fasting and postprandial states in seven subjects with healthy livers and 10 patients with liver disease. In neither group was there any significant difference in the pattern of 14C disappearance. In another 10 patients with liver disease there was no significant change when a loading dose of cholylglycine was given orally two hours beforehand. Clearance of bile acids seems to be unimpaired in all except severe liver disease. The apparent deterioration in endogenous bile acid removal after meals may be due simply to the increased amount of bile acids which are in circulation and available for portosystemic shunting.