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. 1971 Apr;68(4):770-2.
doi: 10.1073/pnas.68.4.770.

Epsilon-(gamma glutamyl) lysine in fibrin: lack of crosslink formation in Factor 13 deficiency

J J Pisano, J S Finlayson, M P Peyton, Y Nagai

Epsilon-(gamma glutamyl) lysine in fibrin: lack of crosslink formation in Factor 13 deficiency

J J Pisano et al. Proc Natl Acad Sci U S A. 1971 Apr.

Abstract

Fibrin clots formed in normal plasma contained about 6 mol of epsilon-(gamma-glutamyl)lysine per mol of fibrin, whereas those formed in plasma from individuals with Factor XIII deficiency contained little or none of this crosslink (0.02-0.64 mol/mol of fibrin). Partial supplementation of the plasma with Factor XIII, at a single concentration tested, commensurately increased the number of crosslinks.

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