Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1971 May;68(5):1065-9.
doi: 10.1073/pnas.68.5.1065.

Linkage disequilibrium in a local population of Drosophila melanogaster

T Mukai, L E Mettler, S I Chigusa

Linkage disequilibrium in a local population of Drosophila melanogaster

T Mukai et al. Proc Natl Acad Sci U S A. 1971 May.

Abstract

461 second chromosomes of Drosophila melanogaster were extracted from a Raleigh, N.C. population and four enzymes controlled by the genes located in this chromosome (alcohol dehydrogenase (EC 1.1.1.1.), malate dehydrogenase-1 (EC 1.1.1.37), glycerol-3-phosphate dehydrogenase-1 (EC 1.1.1.8), and alpha-amylase (EC 3.2.1.1), were assayed electrophoretically and cytologically (salivary-gland chromosomes). Linkage disequilibrium could not be detected among any pair of isozyme genes, except in one case that is best explained as due to a chance error in estimation. Some disequilibria were detected, however, between isozyme genes and polymorphic inversions. The relative viabilities of homozygous and heterozygous combinations of these chromosomes were estimated with respect to the alcohol dehydrogenase alleles and the glycerol-3-phosphate dehydrogenase alleles; no significant difference could be detected. The role of epistasis in natural populations is discussed on the basis of these results.

PubMed Disclaimer

References

    1. Proc Natl Acad Sci U S A. 1968 Jun;60(2):517-24 - PubMed
    1. Genetics. 1966 Aug;54(2):595-609 - PubMed
    1. Genetics. 1969 Apr;61(4):841-58 - PubMed
    1. Genetics. 1967 Mar;55(3):469-81 - PubMed
    1. Am J Hum Genet. 1967 Sep;19(5):681-5 - PubMed

LinkOut - more resources