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. 1971 May;68(5):977-9.
doi: 10.1073/pnas.68.5.977.

Initiation of DNA synthesis in cell cultures by colcemid

J M Vasiliev, I M Gelfand, V I Guelstein

Initiation of DNA synthesis in cell cultures by colcemid

J M Vasiliev et al. Proc Natl Acad Sci U S A. 1971 May.

Abstract

Mitotic inhibitors (colcemid, colchicine, and vinblastine) initiate DNA synthesis in dense stationary cultures of mouse embryo fibroblast-like cells. This initiation is not due to any changes in local cell population density. Relationships between the activation of proliferation and other changes of interphase fibroblast-like cells produced by the mitotic inhibitors (disappearance of cytoplasmic microtubules and activation of movements of cell surface) are discussed.

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References

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