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. 1975 Nov 13;258(5531):121-5.
doi: 10.1038/258121a0.

Cytological detection of mutagen-carcinogen exposure by sister chromatid exchange

P Perry, H J Evans

Cytological detection of mutagen-carcinogen exposure by sister chromatid exchange

P Perry et al. Nature. .

Abstract

A staining technique that detects sister chromatid exchanges (SCEs) has been used to examine the response of chromosomes in cultured Chinese hamster cells to a wide variety of mutagens-carcinogens. The test gives a very sensitive and rapid method for detecting chromosome mutagenicity of chemical agents and provides a powerful new method for detecting environmental mutagens.

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