Comparison of a water-soluble and a water-insoluble podophyllotoxin derivative in murine neoplasms
- PMID: 528564
- PMCID: PMC12253119
- DOI: 10.1007/BF00410644
Comparison of a water-soluble and a water-insoluble podophyllotoxin derivative in murine neoplasms
Abstract
Comparison of a water-soluble (27-487) with a water-insoluble (VP-16-213) podophyllotoxin derivative in seven murine neoplasms revealed slight therapeutic superiortiy of VP-16-213 but also slightly greater toxicity when compared with 27-487. A strikingly good response of the Taper liver tumor to both compounds was observed, providing further incentive to the use of podophyllotoxin derivatives in human hepatomas.
Ein Vergleich eines wasserlöslichen (27–487) mit einem wasserunlöslichen (VP-16-213) Podophyllotoxin-Derivats an sieben verschiedenen Tumoren der Maus ergab eine leichte therapeutische Überlegenheit des VP-16-213, jedoch mit einer etwas größeren Toxizität im Vergleich zu 27–487. Es wurde ein sehr gutes Ansprechen des Taper-Lebertumors gegenüber beiden Verbindungen beobachtet, woraus sich ein weiterer Ansatzpunkt für die Verwendung von Podophyllotoxin-Derivaten bei menschlichen Lebertumoren ergibt.
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