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. 1971 Nov;68(11):2623-6.
doi: 10.1073/pnas.68.11.2623.

Amino acid sequence of the light chain from a mouse myeloma protein with anti-hapten activity: evidence for a third type of light chain

E P Schulenburg, E S Simms, R G Lynch, R A Bradshaw, H N Eisen

Amino acid sequence of the light chain from a mouse myeloma protein with anti-hapten activity: evidence for a third type of light chain

E P Schulenburg et al. Proc Natl Acad Sci U S A. 1971 Nov.

Abstract

A tentative amino acid sequence has been determined for the light chain of a mouse A-myeloma (MOPC-315) protein with anti-2,4-dinitrophenyl activity. An unusual amino acid sequence in the carboxyl-terminal 104 residues suggests that the chain represents a new class of immunoglobulin light chain. The "variable" segment of this chain (amino-terminal 110 residues) differs at only eight positions from the corresponding segment of the lambda chain of a mouse M-myeloma (MOPC-104) protein with anti-dextran activity.

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