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. 1971 Nov;68(11):2818-21.
doi: 10.1073/pnas.68.11.2818.

Compartmentalization of spermine and spermidine in the herpes simplex virion

W Gibson, B Roizman

Compartmentalization of spermine and spermidine in the herpes simplex virion

W Gibson et al. Proc Natl Acad Sci U S A. 1971 Nov.

Abstract

Enveloped particles of herpes simplex virus produced in human cells in culture contained spermidine and spermine, in a molar ratio of 1.6 +/- 0.2. The spermine present within the nucleocapsid is sufficient to neutralize at least 40% of the viral DNA. Disruption of the envelope with nonionic detergent and urea resulted in the selective loss of spermidine. Exogenous ornithine can function as a precursor to host and viral polyamines only before infection.

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