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. 1971 Jun;68(6):1190-1.
doi: 10.1073/pnas.68.6.1190.

Interaction of aromatic amino acids with neutral polyadenylic acid

M Raszka, M Mandel

Interaction of aromatic amino acids with neutral polyadenylic acid

M Raszka et al. Proc Natl Acad Sci U S A. 1971 Jun.

Abstract

The aromatic amino acids tryptophan, phenylalanine, and histidine interact with singlestranded polyadenylic acid [poly(A)] as observed by proton magnetic resonance spectroscopy. The chemical shift of the C(2) and C(8) protons of the adenine moiety of poly(A) is consistent with a destacking of the initially partly-stacked polynucleotide chain by the intercalation of the planar ring structure. The relative magnitude of this interaction is tryptophan>phenylalanine>histidine.

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