doi: 10.1073/pnas.68.6.1341.
Structural basis of the A14 and A15 allotypic specificities in rabbit immunoglobulin G
- PMID: 5288384
- PMCID: PMC389185
- DOI: 10.1073/pnas.68.6.1341
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Structural basis of the A14 and A15 allotypic specificities in rabbit immunoglobulin G
Proc Natl Acad Sci U S A.
1971 Jun.
Abstract
The structural basis for the A14 and A15 allotypic specificities of rabbit immunoglobulin G was investigated with Fe fragments prepared from homozygous rabbits. The presence of threonine in the Cgamma2 region (position 309: Eu numbering) correlates with the A14 allotype; the presence of alanine at this same position correlates with the A15. Now that the sequence of the Cgamma2 region of rabbit IgG has been completely elucidated, a high degree of homology of the constant region domains of rabbit and human gamma chains is apparent (about 60-80%).
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