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. 1971 Jun;68(6):1341-5.
doi: 10.1073/pnas.68.6.1341.

Structural basis of the A14 and A15 allotypic specificities in rabbit immunoglobulin G

E Appella, A Chersi, R G Mage, S Dubiski

Structural basis of the A14 and A15 allotypic specificities in rabbit immunoglobulin G

E Appella et al. Proc Natl Acad Sci U S A. 1971 Jun.

Abstract

The structural basis for the A14 and A15 allotypic specificities of rabbit immunoglobulin G was investigated with Fe fragments prepared from homozygous rabbits. The presence of threonine in the Cgamma2 region (position 309: Eu numbering) correlates with the A14 allotype; the presence of alanine at this same position correlates with the A15. Now that the sequence of the Cgamma2 region of rabbit IgG has been completely elucidated, a high degree of homology of the constant region domains of rabbit and human gamma chains is apparent (about 60-80%).

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References

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