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. 1971 Jun;68(6):1369-71.
doi: 10.1073/pnas.68.6.1369.

RNA-dependent RNA polymerase activity in influenza virions

E Penhoet, H Miller, M Doyle, S Blatti

RNA-dependent RNA polymerase activity in influenza virions

E Penhoet et al. Proc Natl Acad Sci U S A. 1971 Jun.

Abstract

An RNA-dependent RNA polymerase activity has been detected in purified preparations of influenza virus. In contrast to the replicase activity induced in influenza-infected cells, the virion-associated enzyme has an absolute requirement for Mn(++). Most of the RNA synthesized in vitro is complementary to virion RNA.

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