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. 1971 Aug;68(8):1742-7.
doi: 10.1073/pnas.68.8.1742.

Stereospecific and nonspecific interactions of the morphine congener levorphanol in subcellular fractions of mouse brain

A Goldstein, L I Lowney, B K Pal

Stereospecific and nonspecific interactions of the morphine congener levorphanol in subcellular fractions of mouse brain

A Goldstein et al. Proc Natl Acad Sci U S A. 1971 Aug.

Abstract

A METHOD IS DESCRIBED FOR ANALYZING THE ASSOCIATION OF THE OPIATE NARCOTIC LEVORPHANOL WITH BRAIN TISSUE INTO THREE COMPONENTS: nonsaturable, saturable nonspecific, and saturable stereospecific. The method may be of general applicability for the study of the interaction of drugs with body tissues. In mouse brain the stereospecific binding of levorphanol represents only 2% of the total association of drug with tissue, and it was found only in certain membrane fractions. The material responsible for the stereospecific binding might be the opiate receptor.

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References

    1. J Pharmacol Exp Ther. 1963 Dec;142:291-8 - PubMed
    1. Biochem J. 1967 Jul;104(1):148-57 - PubMed
    1. J Pharmacol Exp Ther. 1970 Oct;175(1):84-7 - PubMed
    1. Nature. 1971 Feb 19;229(5286):554-7 - PubMed
    1. J Cell Biol. 1966 Aug;30(2):405-15 - PubMed

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