doi: 10.1073/pnas.68.8.1791.
Translocation of messenger RNA and "accommodation" of fMet-tRNA
- PMID: 5288766
- PMCID: PMC389294
- DOI: 10.1073/pnas.68.8.1791
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Translocation of messenger RNA and "accommodation" of fMet-tRNA
Proc Natl Acad Sci U S A.
1971 Aug.
Abstract
Messenger RNA is moved a distance of approximately three nucleotides in the 5' direction relative to the ribosome during the translocation of peptidyl-tRNA from the A to the P site. This movement is catalyzed by G factor and is dependent on the hydrolysis of GTP. In contrast, mRNA is not moved during the f(2)-catalyzed hydrolysis of GTP that is involved in the activation of ribosome-bound fMet-tRNA. This second type of GTP-dependent reaction has been named "Accommodation".
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