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. 1971 Aug;68(8):1791-5.
doi: 10.1073/pnas.68.8.1791.

Translocation of messenger RNA and "accommodation" of fMet-tRNA

S S Thach, R E Thach

Translocation of messenger RNA and "accommodation" of fMet-tRNA

S S Thach et al. Proc Natl Acad Sci U S A. 1971 Aug.

Abstract

Messenger RNA is moved a distance of approximately three nucleotides in the 5' direction relative to the ribosome during the translocation of peptidyl-tRNA from the A to the P site. This movement is catalyzed by G factor and is dependent on the hydrolysis of GTP. In contrast, mRNA is not moved during the f(2)-catalyzed hydrolysis of GTP that is involved in the activation of ribosome-bound fMet-tRNA. This second type of GTP-dependent reaction has been named "Accommodation".

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References

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