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. 1970 Oct;67(2):799-806.
doi: 10.1073/pnas.67.2.799.

Kinetic model of conduction changes across excitable membranes

M K Jain, R H Marks, E H Cordes

Kinetic model of conduction changes across excitable membranes

M K Jain et al. Proc Natl Acad Sci U S A. 1970 Oct.

Abstract

A kinetic model describing conduction changes across excitable membranes is proposed. It assumes that a population of discrete membrane sites is distributed among several distinct functional states determined by the voltage across the membrane. Interconversion of these states is postulated to occur by first-order reactions. It provides a satisfactory description of the central aspects of excitable membrane behavior, including current-time and current-voltage relationships, action potential, and effects of inhibitors.

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References

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