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. 1971 Dec;68(12):3154-7.
doi: 10.1073/pnas.68.12.3154.

Stimulation of glucose transport in cultures of density-inhibited chick embryo cells

B M Sefton, H Rubin

Stimulation of glucose transport in cultures of density-inhibited chick embryo cells

B M Sefton et al. Proc Natl Acad Sci U S A. 1971 Dec.

Abstract

The rate of glucose transport in sparse, rapidly growing chick-embryo fibroblasts is much greater than that in density-inhibited cells. The addition of fresh chicken serum or trypsin to the medium of density-inhibited cells causes a large increase in the rate of glucose transport that is detectable 15 min after addition. The increase in glucose transport precedes the increase in DNA synthesis by 5-6 hr. Only small changes in rates of transport are seen with nucleosides or a nonmetabolizable amino acid. The increase in glucose transport requires protein synthesis but not RNA or DNA synthesis.

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