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. 1971 Dec 10;174(4014):1136-7.
doi: 10.1126/science.174.4014.1136.

Detection of an antigen associated with acute leukemia

D L Mann, G N Rogentine, R Halterman, B Leventhal

Detection of an antigen associated with acute leukemia

D L Mann et al. Science. .

Abstract

Antiserums to a purified cell membrane component from a Burkitt's lymphoma tissue culture cell line were produced in rabbits. These antiserums were cytotoxic to peripheral white blood cells from 8 of 15 patients with acute leukemia and 5 of 41 relatives, but not to peripheral white blood cells from leukemia patients in clinical remission or from normal individuals. These antiserums appear to be detecting an acute leukemia associated antigen or antigens.

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