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. 1971 Dec;69(4):547-52.
doi: 10.1017/s0022172400021811.

Trials of intranasally administered rubella vaccine

I B Hillary

Trials of intranasally administered rubella vaccine

I B Hillary. J Hyg (Lond). 1971 Dec.

Abstract

No evidence of vaccine virus transmission was found in two studies where Wistar RA 27/3 rubella vaccine was administered intranasally. Vaccine was immunogenic in all of 23 vaccinated children in one study, while in the other only 5 of the 11 vaccinees developed antibody. The reduced seroconversion rate in the latter study appears to have been caused by one or a combination of factors, including the vaccination technique, the presence of infective nasal conditions in vaccinees and the titre of vaccine used.

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References

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