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. 1971 Dec;69(4):553-64.
doi: 10.1017/s0022172400021823.

An M-associated protein antigen (MAP) of group A streptococci

J P Widdowson, W R Maxted, A M Pinney

An M-associated protein antigen (MAP) of group A streptococci

J P Widdowson et al. J Hyg (Lond). 1971 Dec.

Abstract

A streptococcal antigen that is closely associated with the M-antigen, but is not type specific can be detected by means of a complement-fixation test in extracts of M-positive, but not of M-negative, variants of group A streptococci. Purification of acid extracts results in a concomitant increase in the purity both of the type-specific M-antigen and of the M-associated protein (MAP). Antibody to MAP is present in the sera of patients who have had streptococcal infection. The highest titres are found in patients with rheumatic fever.

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