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. 1979 Dec;68(12):1494-8.
doi: 10.1002/jps.2600681208.

Solid-state acetylation of codeine phosphate by aspirin

R N Galante, A J Visalli, D M Patel

Solid-state acetylation of codeine phosphate by aspirin

R N Galante et al. J Pharm Sci. 1979 Dec.

Abstract

A nonsolvolytic (solid-state) acetylation of codeine phosphate in the presence of aspirin to yield acetylcodeine phosphate is reported. GLC assays for the simultaneous determination of aspirin and salicylic acid and codeine and acetylcodeine are described. The apparent heat of activation for codeine phosphate is estimated, and the possible reaction mechanisms are discussed.

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