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. 1968 Jan;3(1):99-105.

Induction by isoniazid and hydrallazine of antinuclear factors in mice

A Cannat, M Seligmann

Induction by isoniazid and hydrallazine of antinuclear factors in mice

A Cannat et al. Clin Exp Immunol. 1968 Jan.

Abstract

The long-term oral administration of isoniazid and hydrallazine to mice resulted in a significant increase in the incidence of antinuclear factors (ANF) in C57B1/6 for both drugs and BALB/c for hydrallazine. ANF disappeared in some mice 2 months after the drugs were discontinued. These findings and the differences observed according to strain, sex and age are discussed in relation to human SLE-like syndromes which may possibly be induced or triggered by drugs.

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