Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1979 Dec;15(2-3):265-70.
doi: 10.1016/0304-3940(79)96124-x.

Antinociceptive action following microinjection of methionine-enkephalin in the nucleus raphe magnus of the rat

A H Dickenson, V Fardin, D Le Bars, J M Besson

Antinociceptive action following microinjection of methionine-enkephalin in the nucleus raphe magnus of the rat

A H Dickenson et al. Neurosci Lett. 1979 Dec.

Abstract

The analgesic effect of the microinjection of low doses of methione-enkephalin (20 micrograms in 0.5 microliter) into the caudal brain stem of the unrestrained rat was investigated by means of one vocalisation test. Immediate short duration significant increases in threshold (21%) were seen from sites in the nucleus raphé magnus (NRM). Delayed effects were seen from sites immediately adjacent to this nucleus; sites more lateral produced no significant effect. These results lend further support to the postulated role of NRM in antinociception.

PubMed Disclaimer

LinkOut - more resources