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. 1975 Dec;24(12):1081-5.
doi: 10.2337/diab.24.12.1081.

Fast and slow axoplasmic flow in sciatic nerve of diabetic rats

R E Schmidt, F M Matschinsky, D A Godfrey, A D Williams, D B McDougal Jr

Fast and slow axoplasmic flow in sciatic nerve of diabetic rats

R E Schmidt et al. Diabetes. 1975 Dec.

Abstract

Accumulation of acetylcholinesterase (AChE) and choline acetylase (ChAc) activities proximal to a tie placed on the sciatic nerve was measured in control, untreated diabetic, and insulin-treated diabetic rats. In the diabetic animals AChE accumulation was reduced by about 20% and ChAc accumulation by about 40%. Insulin treatment eliminated the impairment. It remains an open question whether these reversible functional changes in rat have any counterpart in the diabetic neuropathy of man.

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