[Action mechanism of nicotinic acid on fibrinolysis in vitro and in vivo]
[Article in
Russian]
- PMID: 5317629
Item in Clipboard
[Action mechanism of nicotinic acid on fibrinolysis in vitro and in vivo]
[Article in
Russian]
Vopr Med Khim.
1971 Jul-Aug.
Abstract
Action of nicotinic acid (NA) on components of fibrinolysis in vitro and in vivo and on fibrinolytic activity in vivo was studied. It is shown that NA represses action of inhibitors as well as of fibrinolysis activators. Interaction of NA with plasma in vitro is associated with enhanced fibrinolytic activity on account of inhibition of antiplasmins. Action of NA of fibrinolytic activity of blood during intravenous administration depends on dose. Small doses of NA induce slight activation of fibrinolysis due to binding of antiplasmins. Administration of high doses of NA induces activation of fibrinolysis through thrombogenesis involving central nervous system.
Similar articles
-
[Nicotinic acid and fibrinolysis in humans. II. Tachyphylaxis and dynamic fibrinolytic reactivation (general and regional), caused by "venous" and "arterial" administration of nicotinic acid].Riv Crit Clin Med. 1967 Dec;67(6):484-507. Riv Crit Clin Med. 1967. PMID: 5603692 Italian. No abstract available.
-
Comparative research on the fibrinolytic action of different nicotinic acid derivatives following their prolonged administration into rabbits.Thromb Diath Haemorrh. 1966 Jan 31;15(1):231-7. Thromb Diath Haemorrh. 1966. PMID: 5919803 No abstract available.
-
[Non-enzymatic fibrinolytic agents].Ann Anesthesiol Fr. 1978;19(8):697-702. Ann Anesthesiol Fr. 1978. PMID: 31113 French.
-
Clinical pharmacology and pharmacokinetics of nicotinic acid.Drug Metab Rev. 1979;9(1):99-106. Drug Metab Rev. 1979. PMID: 376259 Review.
-
Platelets in fibrinolytic system.J Physiol Pharmacol. 1995 Dec;46(4):409-18. J Physiol Pharmacol. 1995. PMID: 8770785 Review.