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. 1965 Jul;9(1):67-73.

The functional development of the reticulo-endothelial system. 3. The bactericidal capacity of fixed macrophages of foetal and neonatal chicks and rats

K Karthigasu, P C Reade, C R Jenkin

The functional development of the reticulo-endothelial system. 3. The bactericidal capacity of fixed macrophages of foetal and neonatal chicks and rats

K Karthigasu et al. Immunology. 1965 Jul.

Abstract

The bactericidal capacity of the fixed macrophages of foetal and neonatal rats and chicks was investigated. It has been shown that as a population the phagocytic cells of these embryos lack a bactericidal mechanism for certain strains of Gram-negative bacteria, even in the presence of specific antibody. Neonates, however, were shown to have developed such a mechanism soon after birth. The implication of these findings is discussed in relation to antibody formation.

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