Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1976 Jan 1;143(1):218-24.
doi: 10.1084/jem.143.1.218.

Expression of individual Ia specificities on T and B cells. I. Studies with mitogen-induced blast cells

C David, T Meo, J McCormick, D Shreffler

Expression of individual Ia specificities on T and B cells. I. Studies with mitogen-induced blast cells

C David et al. J Exp Med. .

Abstract

Ia specificities 1-10 were detected on LPS-stimulated splenic lymphocytes and on Con A-stimulated spleen, lymph node, and thymus blasts by direct cytotoxic tests. Since Ia antigens are not readily detectable on resting thymocytes, our results suggest that T cells require some signal before they exhibit full expression of Ia specificities. Absorption-elution studies indicated that most of the Ia specificities detected on T and B cells may be identical. Ia antigens detected by homologous antisera gave much stronger reactions than those detected by cross-reacting antisera.

PubMed Disclaimer

References

    1. J Exp Med. 1975 Jan 1;141(1):263-8 - PubMed
    1. J Exp Med. 1975 Sep 1;142(3):694-700 - PubMed
    1. Science. 1972 Jan 21;175(4019):273-9 - PubMed
    1. J Exp Med. 1973 Dec 1;138(6):1289-304 - PubMed
    1. Proc Natl Acad Sci U S A. 1973 Sep;70(9):2509-14 - PubMed

Publication types