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. 1976 Jan 1;143(1):225-31.
doi: 10.1084/jem.143.1.225.

Hereditary asplenic-athymic mice: transplantation of human myelogenous leukemic cells

B B Lozzio, E A Machado, C B Lozzio, S Lair

Hereditary asplenic-athymic mice: transplantation of human myelogenous leukemic cells

B B Lozzio et al. J Exp Med. .

Abstract

A new animal model characterized by hereditary athymia and asplenia was used as a recipient of chronic myelogenous leukemic (CML) cells with the Philadelphia (Ph1+) chromosome. Transplanted CML cells form solid vascularized tumors containing cells similar to those seen in the patient in a long-term culture. Cells taken from the tumors were nearly triploid, retained all human chromosome markers, and had the same antigenic determinants(s) as cells in culture.

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