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. 1966 Feb;98(2):630-5.
doi: 10.1042/bj0980630.

Methionine synthesis by extracts of Salmonella typhimurium

S E Cauthen, M A Foster, D D Woods

Methionine synthesis by extracts of Salmonella typhimurium

S E Cauthen et al. Biochem J. 1966 Feb.

Abstract

1. Following the genetic studies by Smith (1961) and Smith & Childs (1963) with methionine auxotrophs of Salmonella typhimurium, methionine formation from homocysteine has been investigated with cell-free extracts of this organism. 2. As found with Escherichia coli (Woods, Foster & Guest, 1964), methyl groups are formed by an N(5)N(10)-methylenetetrahydrofolate reductase. They are then transferred to homocysteine by either a simple N(5)-methyltetrahydropteroyl-triglutamate-homocysteine methyltransferase or alternatively a cobalamin-dependent N(5)-methyltetrahydrofolate-homocysteine methyltransferase. 3. S. typhimurium differs from E. coli in being able to synthesize significant amounts of cobalamin.

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