Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1966 Sep;112(3):391-400.
doi: 10.1016/0002-9610(66)90209-1.

Avenues of future research in homotransplantation of the liver with particular reference to hepatic supportive procedures, antilymphocyte serum, and tissue typing

T E Starzl, T L Marchioro, T D Faris, R J McCardle, Y Iwaski

Avenues of future research in homotransplantation of the liver with particular reference to hepatic supportive procedures, antilymphocyte serum, and tissue typing

T E Starzl et al. Am J Surg. 1966 Sep.
No abstract available

PubMed Disclaimer

Figures

Fig. 1
Fig. 1
Course of a dog treated solely with antilymphocyte plasma before and after orthotopic liver homotransplantation. Note the sustained lymphopenia after institution of therapy. Despite significant prolongation of life, the eventual cause of failure was rejection as reflected in the deteriorating liver chemistries.
Fig. 2
Fig. 2
Survival of sixty-four patients who received renal homografts from living volunteer donors between November 1962 and March 1964. No effort at prospective white cell antigen matching was made with these recipients and their donors. Note the poor results when nonrelated donors were used; the loss rate was heavy during the first months and has continued into the second post-operative year. The evident biologic unsuitability of randomly selected nonrelated donors is relevant to liver homotransplantation since all hepatic homografts will have to be procured from cadavers.
Fig. 3
Fig. 3
Results of renal transplantation in patients whose donors were selected by Terasaki’s antigen matching method. Note that survival after eleven months was exactly the same in both the related and nonrelated cases. Compare these results with those in Figure 2.
Fig. 4
Fig. 4
Technic of extracorporeal liver transplantation in the dog. The portal vein is ligated and the hepatic artery anastomosed to the carotid artery. Hepatic venous outflow through the infrarenal inferior vena cava of the graft is channeled into the recipient external jugular vein.
Fig. 5
Fig. 5
Technic of extracorporeal liver homotransplantation used in case I. The superficial femoral artery was anastomosed to the hepatic artery, and the hepatic venous outflow was directed into the femoral system. The liver was left in situ for three and a half days.
Fig. 6
Fig. 6
Course of a seventeen year old boy dying of hepatitis who was provided with an extracorporeal liver homograft. There was prompt clearing of bilirubinemia and alkaline phosphatemia but little evidence of synthetic function.
Fig. 7
Fig. 7
Technic for extracorporeal transplantation of a chimpanzee heterograft (case II). The details are similar to those in case I except that the femoral vein was transected and the distal end anastornosed to the portal vein.
See this image and copyright information in PMC

References

    1. Starzl TE, Marchioro TL, Porter KA. Advances in homotransplantation of the liver. In: Welch C, editor. Advances in Surgery. Chicago: Yearbook Medical Publishers, Inc; 1966.
    1. Starzl TE, Marchioro TL, Faris TD. Liver transplantation. Ann Int Med. 1966;64:473. - PubMed
    1. Moore FD. Personal communication. Apr, 1966.
    1. Mikaeloff P, Kestens PJ, Dureau G. Transplantation orthotopique du Foie chez le chien après consérvation de l’organe par perfusion. Mem Acad chir. 1965;91:711. - PubMed
    1. Marchioro TL, Porter KA, Dickinson TC, Faris TD, Starzl TE. Physiologic requirements for auxiliary liver homotransplantation. Surg Gynec & Obst. 1965;121:17. - PMC - PubMed

LinkOut - more resources