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. 1966 Dec 23;154(3756):1572-3.
doi: 10.1126/science.154.3756.1572.

Control of the activity of Escherichia coli carbamoyl phosphate synthetase by antagonistic allosteric effectors

A Piérard

Control of the activity of Escherichia coli carbamoyl phosphate synthetase by antagonistic allosteric effectors

A Piérard. Science. .

Abstract

The synthesis of carbamoyl phosphate required in both arginine and pyrimidine biosyntheses is carried out by a single enzyme in Escherichia coli. Opposed effects of pyrimidine nucleotides and of ornithine on the activity of the enzyme ensure a proper supply of carbamoyl phosphate according to the needs of the two biosynthetic sequences.

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