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. 1975 Nov 8;2(7941):899-901.
doi: 10.1016/s0140-6736(75)92130-3.

Formation of virosomes from influenza subunits and liposomes

J D Almeida, D C Edwards, C M Brand, T D Heath

Formation of virosomes from influenza subunits and liposomes

J D Almeida et al. Lancet. .

Abstract

The surface haemagglutinin and neuraminidase projections of influenza virus were removed from the viral envelope, purified, and relocated on the surface of unilamellar liposomes. The resulting structures were examined in the electron microscope and found to resemble the original virus. Units of both the viral haemagglutinin and viral neuraminidase could be discerned. The name virosome is proposed for these new bodies.

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