doi: 10.1128/jb.140.3.1123-1125.1979.
Local anesthetics block induction of the Pseudomonas alk regulon
- PMID: 533765
- PMCID: PMC216764
- DOI: 10.1128/jb.140.3.1123-1125.1979
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Local anesthetics block induction of the Pseudomonas alk regulon
J Bacteriol.
1979 Dec.
Abstract
The local anesthetics procaine and piperocaine blocked induction of the plasmid-determined enzymatic activities involved in the metabolism of n-alkanes in Pseudomonas putida. Procaine reversibly inhibited existing alkane hydroxylase activity. Induction of a soluble aliphatic amidase activity was not affected. These results support the hypothesis that induction of the plasmid-determined alkane metabolic system in P. putida involves a membrane component(s).
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