doi: 10.1084/jem.130.4.867.
Cells involved in the immune response. 8. The relationship between the loss and reappearance of antigen-reactive cells and immune responsiveness after irradiation of normal adult rabbits
- PMID: 5343438
- PMCID: PMC2138722
- DOI: 10.1084/jem.130.4.867
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Cells involved in the immune response. 8. The relationship between the loss and reappearance of antigen-reactive cells and immune responsiveness after irradiation of normal adult rabbits
J Exp Med.
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Abstract
By appropriate irradiation and cell transfer experiments, a direct correlation was observed between the presence of viable and immunologically active antigen-reactive cells and the capacity of the rabbits to respond following immunization. Rabbits given 800 R total body irradiation were unable to elicit a humoral immune response nor did they possess significant numbers of antigen-reactive cells. The ability to respond with humoral antibody formation did not reappear until antigen-reactive cells could be detected. These results strongly indicate that the presence of competent antigen-reactive cells are necessary for the successful induction of the humoral immune response in the rabbit.
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