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. 1969 Oct 1;130(4):867-76.
doi: 10.1084/jem.130.4.867.

Cells involved in the immune response. 8. The relationship between the loss and reappearance of antigen-reactive cells and immune responsiveness after irradiation of normal adult rabbits

N I Abdou, B Rose, M Richter

Cells involved in the immune response. 8. The relationship between the loss and reappearance of antigen-reactive cells and immune responsiveness after irradiation of normal adult rabbits

N I Abdou et al. J Exp Med. .

Abstract

By appropriate irradiation and cell transfer experiments, a direct correlation was observed between the presence of viable and immunologically active antigen-reactive cells and the capacity of the rabbits to respond following immunization. Rabbits given 800 R total body irradiation were unable to elicit a humoral immune response nor did they possess significant numbers of antigen-reactive cells. The ability to respond with humoral antibody formation did not reappear until antigen-reactive cells could be detected. These results strongly indicate that the presence of competent antigen-reactive cells are necessary for the successful induction of the humoral immune response in the rabbit.

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References

    1. Science. 1963 Apr 26;140(3565):405 - PubMed
    1. J Exp Med. 1969 Jun 1;129(6):1261-73 - PubMed
    1. Immunology. 1968 Dec;15(6):827-35 - PubMed
    1. J Infect Dis. 1954 Sep-Oct;95(2):117-33 - PubMed
    1. J Exp Med. 1963 May 1;117:833-48 - PubMed