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. 1969 Oct;114(4):801-6.
doi: 10.1042/bj1140801.

The incorporation of a hydrogen atom at C-15 of cholesterol biosynthesized from squalene

M Akhtar, A D Rahimtula, D C Wilton

The incorporation of a hydrogen atom at C-15 of cholesterol biosynthesized from squalene

M Akhtar et al. Biochem J. 1969 Oct.

Abstract

Cholesterol is biosynthesized from squalene in the presence of tritiated water. Chemical degradation reveals that a considerable percentage of the total radioactivity is present at C-15. This result confirms the previous observations on the involvement of a C-15 hydrogen atom in cholesterol biosynthesis.

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